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PRIMe researchers from diverse fields of study, nationalities, and backgrounds come together and collaborate “under-one-roof” to conduct interdisciplinary and integrative research.

TSUMAKI Noriyuki

Professor/PI

Osaka University Graduate School of Medicine

Related Website:
Graduate School of Medicine, Faculty of Medicine | Tissue Biochemistry researchmap

Creation of Biodigital Twins for Cartilage Biology and Pathology

To construct biodigial twins for cartilage, we collect genome-wide digital information in multiple aspects. One aspect includes collecting data from iPSC-derived cartilage organoids implanted into diseased sites such as join surface defects, clarifying courses of both progression and healing of cartilage diseases. We also collect data from cartilage samples from patients with osteoarthritis to create disease models.

Research Outline

References

  1. Abe, K., et al., Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect. Nat Commun, in press, 2023.
  2. Kamatani, T., et al., Human iPS cell-derived cartilaginous tissue spatially and functionally replaces nucleus pulposus. Biomaterials, 284: p. 121491, 2022.
  3. Yahara, Y., et al., Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3. Nat Commun, 7: p. 10959, 2016.
  4. Yamashita, A., et al., Generation of Scaffoldless Hyaline Cartilaginous Tissue from Human iPSCs. Stem Cell Reports, 4(3): p. 404-418, 2015.
  5. Yamashita, A., et al., Statin treatment rescues FGFR3 skeletal dysplasia phenotypes. Nature, 513(7519): p. 507-511, 2014.
  6. Hiramatsu, K., et al., Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors. J Clin Invest, 121(2): p. 640-657, 2011.
Organoid biomedical Science/Tissue Biochemistry Systems
Professor