NISHIDA Kohji
Center Director/Professor/PI
Osaka University Graduate School of Medicine
Elucidation of Mechanism for Retinal and Optic Nerve Degeneration through Human Metaverse Medicine
Our group made a breakthrough technique for the first-ever in vitro organogenesis of the entire human eye (named SEAM), from human iPS cells and succeeded in creating the world’s first human organoids of cornea, conjunctiva, lacrimal gland and retina-retinal pigment epithelium. We plan to create a biodigital twin for age-related macular degeneration and retinitis pigmentosa.
Research Outline
References
- Hayashi R, Okubo T, Kudo Y, Ishikawa Y, maizumi T, Suzuki K, Shibata S, Katayama T, Park SJ, Young RD , Quantock AJ, Nishida K. Generation of 3D lacrimal gland organoids from human pluripotent stem cells. Nature. 605(7908):126-131, 2022.
- Nomi K, Hayashi R, Ishikawa Y, Kobayashi Y, Katayama T, Quantock AJ, Nishida K. Generation of functional conjunctival epithelium, including goblet cells, from human iPSCs. Cell Rep. 34(5):108715. 2021.
- Hayashi R, Ishikawa Y, Sasamoto Y, Katori R, Nomura N, Ichikawa T, Araki S, Soma T, Kawasaki S, Sekiguchi K, Quantock AJ, Tsujikawa M, Nishida K. Co-ordinated ocular development from human iPS cells and recovery of corneal function. Nature. 531(7594):376-80. 2016.
- Nishida K, Yamato M, Hayashida Y, Watanabe K, Yamamoto K, Adachi E, Nagai S, Kikuchi A, Maeda N, Watanabe H, Okano T, Tano Y. Corneal reconstruction with tissue-engineered cell sheets composed of autologous oral mucosal epithelium. N Engl J Med. 351(12):1187-96. 2004.
