Research
Jun 26, 2025
Groundbreaking Study Reveals Critical Role of Iron, Paving the Way for New Treatments of Mycetoma
Research group led by Specially Appointed Professor Imad Abugessaisa, in collaboration with Associate Professor Wendy van de Sande from Erasmus University Medical Center in the Netherlands, headed a consortium from RIKEN IMS (Japan), Erasmus MC (Netherlands), Maynooth University (Ireland), and the Mycetoma Research Center (WHO collaborating center on Mycetoma and Skin Neglected Tropical Diseases, Sudan). The team used state-of-the-art histology techniques, omics technologies, and computational biology to unravel the formation and development of mycetoma grains.
| Title | Iron regulatory pathways differentially expressed during Madurella mycetomatis grain development in Galleria mellonella |
| Authors | Imad Abugessaisa, Mickey Konings, Ri-Ichiroh Manabe, Cathal M. Murphy, Tsugumi Kawashima, Akira Hasegawa, Chitose Takahashi, Michihira Tagami, Yasushi Okazaki, Kimberly Eadie, Wilson Lim, Sean Doyle, Annelies Verbon, Ahmed H. Fahal, Takeya Kasukawa and Wendy W.J. van de Sande |
| DOI | https://doi.org/10.1038/s41467-025-60875-2 |
| Journal | Nature Communications |
| Published date | June 25, 2025 |