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Research
Apr 24, 2025
Deveopment of multi-zonal liver organoids from human pluripotent stem cells

PRIMe Deputy Director Prof. Takanori Takebe and his research group acheived in creating multi-zonal liver organoids from human iPSC. This study leads the medical treatment for liver diseases one step closer to culturing patient’s own liver replacement tissue instead of liver transplantation.

TitleMulti-zonal liver organoids from human pluripotent stem cells
AuthorsHasan Al Reza, Connie Santangelo, Kentaro Iwasawa, Abid Al Reza, Sachiko Sekiya, Kathryn Glaser, Alexander Bondoc, Jonathan Merola & Takanori Takebe
DOIhttps://doi.org/10.1038/s41586-025-08850-1
JournalNature
Published dateApril 16, 2025

In Rodents, New Human “Multi-Zonal” Liver Organoids Improve Injury Survival | Research Horizons | Cincinnati Children’s