Research
Sep 27, 2024
SMAD3 mediates the specification of human iPSC-derived epicardium into progenitors for the cardiac pericyte lineage
Dr. Antonio Lucena-Cacace (WPI-PRIMe, Osaka University), Dr. Yoshinori Yoshida (CiRA, Kyoto University) and their research group discovered that SMAD3 mediates the specification of human induced pluripotent stem cell-derived epicardium into progenitors for the cardiac pericyte lineage. This achievement may be a biological knowledge-base of a new approach of a treatment for cardiovascular diseases.
| Title | SMAD3 mediates the specification of human induced pluripotent stem cell-derived epicardium into progenitors for the cardiac pericyte lineage |
| Authors | Yutaro Miyoshi#, Antonio Lucena-Cacace#*, Yu Tian, Yasuko Matsumura, Kanae Tani, Misato Nishikawa, Megumi Narita, Takeshi Kimura, Koh Ono, Yoshinori Yoshida* # : Co-first Authors * : Co-corresponding Authors |
| DOI | https://doi.org/10.1016/j.stemcr.2024.08.008 |
| Journal | Stem Cell Reports |
| Published date | September 27, 2024 |
ヒトiPS細胞由来心外膜細胞から血管新生や心筋増殖を促す「心臓周皮細胞」を作製 | CiRA | Kyoto University (Press release in Japanese)