Research
Aug 1, 2024
Quantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues
The research group of Yukinori Okada (Graduate School of Medicine, WPI-IFReC, WPI-PRIMe in Osaka University/RIKEN/The University of Tokyo) developed scLinaX for directly quantifying relative gene expression from the inactivated X chromosome with droplet-based single-cell RNA-sequencing (scRNA-seq) data. The scLinaX and differentially expressed gene analyses with large-scale blood scRNA-seq datasets consistently identified the stronger escape in lymphocytes than in myeloid cells.
| Title | Quantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues |
| Authors | Yoshihiko Tomofuji*, Ryuya Edahiro, Kyuto Sonehara, Yuya Shirai, Kian Hong Kock, Qingbo S. Wang, Shinichi Namba, Jonathan Moody, Yoshinari Ando, Akari Suzuki, Tomohiro Yata, Kotaro Ogawa, Tatsuhiko Naito, Ho Namkoong, Quy Xiao Xuan Lin, Eliora Violain Buyamin, Le Min Tan, Radhika Sonthalia, Kyung Yeon Han, Hiromu Tanaka, Ho Lee, Asian Immune Diversity Atlas Network, Japan COVID-19 Task Force, The BioBank Japan Project, Tatsusada Okuno, Boxiang Liu, Koichi Matsuda, Koichi Fukunaga, Hideki Mochizuki, Woong-Yang Park, Kazuhiko Yamamoto, Chung-Chau Hon, Jay W. Shin, Shyam Prabhakar, Atsushi Kumanogoh, Yukinori Okada* *Corresponding author |
| DOI | https://doi.org/10.1016/j.xgen.2024.100625 |
| Journal | Cell Genomics |
| Published date | July 30, 2024 (online) |