Protein screening is an experimental method employed to identify, analyze, and characterize proteins according to their structure and functions. This process plays a crucial role in diverse applications, including drug discovery and disease diagnostics.
Takahiro Nemoto (WPI-PRIMe), Deniz Dalkara (Institut de la Vision, Sorbonne Université), Ulisse Ferrari(Institut de la Vision, Sorbonne Université) and the research group developed ACIDES (Accurate Condence Intervals for Directed Evolution Scores), a computational method to empower the analysis of directed evolution and deep mutational scanning experiments. ACIDES will allow experimentalists to reliably estimate variant performance, aid protein engineering and research pipelines in a range of applications, including gene therapy.