Biodigital Twin of Heart, Wearable, Implantable Devices and AI/ICT for Prediction of Heart Attack, Neuromodulation Therapy

invented the wearable device hitoe® ,neuro-cardiac implant electrodes, Tensor cardiography®. Using these devices, machine learning, and medical ICT platform to develop 1.biodigital twin of the heart, 2.devices for detecting signs of heart attack and 3. neuromodulatory therapy of heart disease.

Research Outline

1.Invention of textile bioelectrode “hitoe” which is low noise and biocompatible bioelectrode made of fabric composite of nanofibers and conductive polymer PEDOTPSS. World‘s first practical application of wearable electrodes for Holter ECG for continuous measurement for more than 2 weeks. This material also used for detection of biomedical signals EMG EEG and stimulation using novel wearable-type and implant-type bioelectrodes for neuromodulation therapy ^1,2.

2.Invention of “Tensor cardiography” A New Analysis Method of ECG by Graph Signal Processing and Point Process in order to estimate abnormalities in myocardial action potentials from ECG distortions ³.

3.Research on stem cell transplantation and gene therapy for the treatment of spinal cord injury and Alzheimer’s disease^4,5.

References

1. Conductive polymer combined silk fiber bundle for bioelectrical signal recording.
   S, Nakashima H, Torimitsu K. PLoS One. 2012;7(4):e33689. doi: 10.1371/journal.pone.0033689. Epub 2012 Apr 6.
2. Tsukada YT, Tokita M, Murata H, Hirasawa Y2, Yodogawa K, Iwasaki YK, Asai K, Shimizu W, Kasai N, Nakashima H, Tsukada S.　Validation of wearable textile electrodes for ECG monitoring.　 Heart Vessels. 2019 Jul;34(7):1203-1211. doi: 10.1007/s00380-019-01347-8. Epub 2019 Jan 24.
3. Wearable Textile Electrodes for Long-term Vector ECG monitoring “Tensor Cardiography”　IEEE・ISMICT2020（14th International Symposium on Medical ICT）
4. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer’s disease.
   Nagahara AH, Merrill DA, Coppola G, Tsukada S, Schroeder BE, Shaked GM, Wang L, Blesch A, Kim A, Conner JM, Rockenstein E, Chao MV, Koo EH, Geschwind D, Masliah E, Chiba AA, Tuszynski MH. Nat Med. 2009 Mar;15(3):331-7. doi: 10.1038/nm.1912. Epub 2009 Feb 8.
5. Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury K. Kadoya^⋆, S. Tsukada^⋆, P. Lu, G. Coppola, D. Geschwind, M. T Filbin, A. Blesch, M. H Tuszynski,  Neuron 2009 Oct 29;64(2):165-72..　（^⋆Equal contribution）