Organoid Modeling for Human Growth and Metabolic Deficiencies

Normal and patient iPSC-derived organoids carrying molecular defects causal of growth/metabolic deficiencies, will be used to investigate mechanistic responses to hormonal & cytokine cues, to recapitulate human growth phenotypes, towards developing & building growth datasets for Human Growth Biodigital twin.

Research content

References

Selected collaborative Publications (from >130):
N Engl J Med, 2003; Nat Commun, 2018;
JCEM 2008, 2009, 2011, 2012, 2022, multiple; EMBO Mol Med, 2016;
Endocr Rev: 2011, 2019; Rev Endocr Metab Disord, 2021
Nat Genet, 2019; J Clin Immunol, 2021; Am J Respir Crit Care Med, 2022
Cell, 2022
Mol Cell Endocrinol 2023