Hyperpolarized MRI/NMR

Hyperpolarization technology can improve the sensitivity of MRI/NMR. In this study, we visualize the metabolic process in organoids with hyperpolarized MRI/NMR. We attempt to understand disease models at the quantum mechanical level by comparing data in organoid, in vivo, in vitro, and in silico.

Research Outline

References

1. Z. J. Wang, et al., “Hyperpolarized 13C MRI: State of the Art and Future Directions” Radiology (2019) 291, 273–284
2. K Tateishi, MN, et al., “Room temperature hyperpolarization of nuclear spins in bulk” Proc Nat Acad Sci (2014) 111, 7527-7530
3. A. Kagawa, MN, et al., “High-field NMR with dissolution triplet-DNP” J. Magn. Reson. (2019) 309, 106623